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I am a lecturer in Statistical Genetics in the Department of Population Health Sciences. I did a Biological Sciences BSc at Fudan University (Shanghai, China), where I became interested in the interdisciplinary convergence of biology and data science. I undertook my PhD in Statistical Genetics at University of Birmingham, where I developed methodologies for quantitative genetic analysis in autotetraploid species. With the motivation to translate research findings into personalized medicine, I joined the Â鶹ÊÓƵ in 2020 as a postdoctoral research associate, working on multi-ancestry genome-wide association studies for respiratory disease and thyroid disease.

I have a keen interest in developing polygenic risk scores for stratified medicine and understanding multiple long-term conditions. My other interests include development of research capacity in low- and middle-income countries.

For a full list of publications see: https://scholar.google.com/citations?user=vA8qv4AAAAAJ&hl=en&oi=ao

Sayers I, John C, Chen J and Hall IP. (2024) Genetics of chronic respiratory disease. Nature Review Genetics 25(8): 534-547.

Chen J, Shrine N, Izquierdo A, Guyatt AL, Volzke H, London SJ. et al. (2024) Genetic risk score-informed re-evaluation of spirometry quality control to maximise power in epidemiological studies of lung function. https://www.medrxiv.org/content/10.1101/2024.07.31.24311269v1.

Shrine N*, Izquierdo AG*, Chen J*, Packer R*, Hall RJ, Guyatt AL, et al. (2023) Multi-ancestry genome-wide association study improves resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nature Genetics 55:410-422. (Cover paper, joint-first authorship)

Williams AT*, Chen J*, Coley K, Batini C, Izquierdo A, Packer R, et al. (2023) Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathway and association with thyroid disease. Nature Communications 14:6713. (Joint-first authorship)

Polygenic risk score analysis

Genetic epidemiology of multiple long-term conditions

MSc Medical Statistics (module “Computationally Intensive Methodologies”)

BSc in Biological Sciences, Fudan University, Shanghai, China

PhD in Statistical Genetics, University of Birmingham, UK